Post-Doctoral Research Fellow - Experimental Neuropathology Unit

Post-Doctoral Research Fellow - Experimental Neuropathology Unit Join the Post-Doctoral Research Fellow - Experimental Neuropathology Unit role at Humanitas. Location: Rozzano, IT, 20089 Department: Biomedical Sciences PI Reference: Martina Absinta Contract Type: Fixed-term contract, 12 months renewable Position Summary Humanitas University is seeking a highly motivated Post-Doctoral Research Fellow with a background in Biology or Biotechnology to support research activities within the Experimental Neuropathology Unit. The selected candidate will contribute to the project: Title: Dissecting microglia vulnerability to stress response in Multiple Sclerosis through human iPSC modelling Objective: Investigate molecular mechanisms underlying microglial vulnerability to cellular senescence in Multiple Sclerosis (MS), using human iPSC-derived models and advanced gene editing techniques. Research Project Overview The MiST-MS project shifts focus from lymphocyte-driven inflammation to glial cell responses, particularly microglial senescence, as key drivers of chronic inflammation and disability in MS. hiPSC-derived microglia models Genome-wide CRISPR-Cas9 screenings Single-cell CRISPR-seq and multi-omics integration Organoid-based brain aging models This innovative pipeline aims to identify therapeutic targets to halt MS progression by rejuvenating microglial function. Key Responsibilities Culturing human iPSCs, neural precursor cells, and brain organoids Performing CRISPR/Cas9 gene editing Differentiation of hiPSCs into microglia and other neural cell types Data analysis and interpretation in collaboration with computational teams Required Qualifications PhD in Biology, Biotechnology, Molecular Biology, Biomedical Sciences, or related fields Proven experience in hiPSC culture and differentiation, and CRISPR/Cas9 gene editing Fluent written and spoken English Strong scientific and professional track record Preferred Skills Experience with brain organoid models Familiarity with single-cell sequencing and multi-omics data Ability to work independently and collaboratively in a multidisciplinary team Required Documents For Your Application Cover letter explaining why you want to join the team Update CV Contact information of three referees J-18808-Ljbffr

Location: Rozzano, Lombardia, IT

Posted Date: 10/9/2025