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Scientist II, Biomarkers

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Job Location

New Haven, CT, United States

Job Description

*This position will be based in New Haven, CT with the expectation of working onsite *

Position Summary

The Scientist II in Biomarker Development supports R&D programs through the identification of preclinical and clinical biomarkers of disease activity, verify mechanism of action and/or clinical response to therapeutic treatment, which forms the basis of a biomarker strategy to support drug development.  The Biomarker Scientist II provides biomarker leadership on cross-functional teams as well as leads the development of bioanalytical methods including chemical, protein, nucleic and/or cell-based methodology.  The Scientist II designs and performs experiments at the bench, interprets and presents the data, and incorporates proven methodology to support biomarker sample analysis and/or diagnostic development.


Principal Responsibilities

  • Subject matter expert and individual contributor able to identify or discover biomarkers that correlate to disease, treatment response and/or clinical endpoint

  • Serve as functional representative to project teams, provide input and guide biomarker discussions, and confidently lead subteam(s) as needed

  • Able to perform independent research and formulate biomarker strategies with testable hypotheses to support drug development. Design, execute and troubleshoot experiments, interpret data, synthesize, and communicate conclusions

  • Develop bioanalytical methods including chemical, protein, nucleotide and/or cell-based methods, optimize for analytical performance and validate to support sample testing in regulated studies

  • Able to manage & mentor junior scientists or associates as well as manage external work performed at contracted vendors

  • Multi-task multiple projects, prioritize and allocating efforts appropriately to align with project and/or corporate objectives

  • Distill complex issues, articulate potential solutions, and prioritize appropriately, but may seek coaching and feedback

  • Strong interpersonal skills and ability to work well as member of a team

  • Excellent communication and presentation skills. Able to communicate the scientific “story” within Alexion and at external meetings and conferences



  • The Research Scientist II should have 3 - 5 years of relevant academic or industrial postdoctoral experience and exemplify the following attributes:

    • Proven track record of creativity, innovation, independent thought and experimental design to deliver definitive results

    • Ability to successfully execute and manage multiple projects simultaneously

    • Strong collaborative and interpersonal skills; ability to successfully work as part of a team but also able to lead an inter-departmental project or initiative involving other contributors to accomplish a defined goal

    • Excellent oral and written communication skills are essential. Solid track record of significant contribution to publications in peer reviewed journals and/or presentations at scientific meetings

  • Expertise in development, optimization, and execution of biochemical, molecular and protein-based methods (e.g. expression analysis, chromatography, Westerns, enzyme assays, ligand-binding assays, IHC, siRNA, RT-PCR, etc.). Next-Gen Sequencing and/or single-cell analysis and/or transcriptomic/proteomic experience would be a plus

  • Expertise in cell culture and cell-based assay development and validation including flow cytometry, confocal, reporter and signaling assays (utilizing primary, stem and/or transformed cells) in support of research and development initiatives

  • Ability to identify relevant biomarkers that connect disease pathophysiology and response to treatment, develop, optimize, and validate biomarker assays in support of pre-clinical and clinical drug studies

  • Experience in transferring assays to CROs and successful validation and delivery of quality results under tight timelines, either individually or as part of a team

  • Familiarity with clinical trial and lab manual design for optimum sample collection and processing, sample testing, data analysis and interpretation is preferred

  • Subject matter expertise in neuroinflammatory and/or neurodegenerative disorders and/or complement-mediated disease is strongly preferred



  • Ph.D. or equivalent degree in Neurobiology or Cell Biology, Immunology, Pharmacology, Biochemistry, or other biomedical science with 3 - 5 years of relevant academic and/or pharmaceutical industry postdoctoral experience





Some opportunities happen only once in a lifetime - like a job where you have the extraordinary opportunity to change lives. At Alexion, such opportunities arise through our unwavering mission to serve patients and families affected by rare diseases. These patients are our guiding star, and we act with integrity, urgency, and discipline because we know their lives are at stake.

Alexion is a global biopharmaceutical company focused on serving patients and families affected by rare diseases and devastating conditions through the discovery, development and commercialization of life-changing medicines. As a leader in rare diseases for more than 25 years, Alexion has developed and commercializes two approved complement inhibitors to treat patients with paroxysmal nocturnal hemoglobinuria (PNH) and atypical hemolytic uremic syndrome (aHUS), as well as the first and only approved complement inhibitor to treat anti-acetylcholine receptor (AchR) antibody-positive generalized myasthenia gravis (gMG) and neuromyelitis optica spectrum disorder (NMOSD). Alexion also has two highly innovative enzyme replacement therapies for patients with life-threatening and ultra-rare metabolic disorders, hypophosphatasia (HPP) and lysosomal acid lipase deficiency (LAL-D) as well as the first and only approved Factor Xa inhibitor reversal agent. In addition, the company is developing several mid-to-late-stage therapies, including a copper-binding agent for Wilson disease, an anti-neonatal Fc receptor (FcRn) antibody for rare Immunoglobulin G (IgG)-mediated diseases and an oral Factor D inhibitor as well as several early-stage therapies, including one for light chain (AL) amyloidosis, a second oral Factor D inhibitor and a third complement inhibitor. Alexion focuses its research efforts on novel molecules and targets in the complement cascade and its development efforts on the core therapeutic areas of hematology, nephrology, neurology, metabolic disorders and cardiology. Headquartered in Boston, Massachusetts, Alexion has offices around the globe and serves patients in more than 50 countries. Further information about Alexion can be found at:

As a leading employer in our industry, Alexion is proud to offer a highly competitive package of base and incentive compensation as well as a comprehensive benefits program designed to support the health, wellness and financial security of our employees and their families. Benefits include group medical, vision and dental coverage, group and supplemental life insurance, 401(k) with company match, tuition reimbursement, relocation assistance and much more.

Location: New Haven, CT, US

Posted Date: 4/20/2021
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April 20, 2021
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